Central adrenal insufficiency: open issues regarding diagnosis and glucocorticoid treatment

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Diagnosis of adrenal insufficiency.

BACKGROUND The cosyntropin stimulation test is the initial endocrine evaluation of suspected primary or secondary adrenal insufficiency. PURPOSE To critically review the utility of the cosyntropin stimulation test for evaluating adrenal insufficiency. DATA SOURCES The MEDLINE database was searched from 1966 to 2002 for all English-language papers related to the diagnosis of adrenal insuffic...

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Diagnosis and management of adrenal insufficiency.

Adrenal insufficiency continues to be a challenge for patients, their physicians, and researchers. During the past decade, long-term studies have shown increased mortality and morbidity and impaired quality of life in patients with adrenal insufficiency. These findings might, at least partially, be due to the failure of glucocorticoid replacement therapy to closely resemble physiological diurna...

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Adrenal insufficiency after glucocorticoid withdrawal in children with rheumatic diseases.

AIM  Glucocorticoids (GCs) are often used for the treatment of rheumatic disorders. However, doses are prescribed, which may suppress the hypothalamic-pituitary-adrenal (HPA) axis. After GC withdrawal, recovery of the HPA axis may be delayed putting the patient at risk for adrenal insufficiency. We assessed adrenal function and factors influencing adrenal responsiveness after termination of GC ...

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ژورنال

عنوان ژورنال: Clinical Chemistry and Laboratory Medicine (CCLM)

سال: 2019

ISSN: 1437-4331,1434-6621

DOI: 10.1515/cclm-2018-0824